Pesticide dangers in developing countries have gained wider recognition of late, and are being addressed by international policy initiatives. These initiatives have opened up new avenues of dialogues at the national and international levels between different players. Conventions and other international instruments to address trade and production of hazardous pesticides, and the need for corporate accountability provide great opportunities. The Rotterdam Convention on the Prior Informed Consent Procedure for Certain Hazardous Chemicals and Pesticides in International Trade (PIC treaty) and Stockholm Convention on Persistent Organic Pollutants (POPs) directly address pesticide hazards. Meanwhile, the International Code on Conduct on the Distribution and Use of Pesticides (FAO Code), and the Intergovernmental Forum on Chemical Safety (IFCS) and Strategic Approach to International Chemicals Management (SAICM) processes can provide detailed guidance that can advance the necessity for alternatives, and support and promote sustainable agriculture.